Binary pan-cancer
WebBinary pan-cancer classes with distinct vulnerabilities defined by pro- or anti-cancer YAP/TEAD activity. J. Pearson, Katherine Huang, +23 authors R. Bremner Biology, Medicine Cancer cell 2024 52 YAP1 is a Prognostic Biomarker and Correlated with Immune Cell Infiltration in Pancreatic Cancer K. Sun, Xuede Zhang, Xiao-yang Liu, P. Lu WebAug 1, 2024 · To pave the way for the pan-cancer comparative analysis of TIMEs at a single-cell level, we first built a pan-cancer immune cell reference by integrating eight single-cell transcriptome datasets across six types of cancers (Supplementary Table S1).
Binary pan-cancer
Did you know?
WebSep 15, 2024 · A growing body of evidence has shown that circular RNA (circRNA) is a promising exosomal cancer biomarker candidate. However, global circRNA alterations in cancer and the underlying mechanism, essential for identification of ideal circRNA cancer biomarkers, remain under investigation. We comparatively analyzed the circRNA … WebPan-cancer analysis aims to examine the similarities and differences among the genomic and cellular alterations found across diverse tumor types. [1] [2] …
WebAug 9, 2024 · Here, we define pan-cancer binary classes based on distinct expression of YAP and YAP-responsive adhesion regulators. Combining informatics with in vivo and in vitro gain- and loss-of-function studies across multiple murine and human tumor types, we show that opposite pro- or anti-cancer YAP activity functionally defines binary YAP on or …
WebHere, we define pan-cancer binary classes based on distinct expression of YAP and YAP-responsive adhesion regulators. Combining informatics with in vivo and in vitro gain- and loss-of-function studies across multiple murine and human tumor types, we show that opposite pro- or anti-cancer YAP activity functionally defines binary YAPon or YAPoff ... WebSep 24, 2024 · The YAP off class consisted of virtually all blood cancers (leukemia, lymphoma, and myeloma), many neural cancers (retinoblastoma, low-grade glioma, neuroblastoma) as well as small cell and well-differentiated neuroendocrine cancers from many tissues, including lung, prostate, breast and the gastrointestinal tract.
WebHome: Cell Press
Pan-cancer analysis aims to examine the similarities and differences among the genomic and cellular alterations found across diverse tumor types. International efforts have performed pan-cancer analysis on exomes and the whole genomes of cancers, the latter including their non-coding regions. In 2024, The Cancer Genome Atlas (TCGA) Research Network used exome, transcriptome, and DNA methylome data to develop an integrated picture of commonalities, differences, and e… prophila collection briefmarkenWebAug 1, 2024 · The binary cancer groups exhibit distinct YAP-dependent adhesive behavior and pharmaceutical vulnerabilities, underscoring clinical relevance. Mechanistically, distinct YAP/TEAD enhancers in YAP or YAP cancers deploy anti-cancer integrin or pro-cancer proliferative programs, respectively. prophilaxis setWebJul 16, 2024 · "The simple binary rule we uncovered may expose strategies to treat many cancer types that fall into either the YAPoff or YAPon superclasses," Pearson said. ... prophicactic antibiotic medicationWebFigure 1. Features and mechanisms underlying binary YAP on and YAP off cancer superclasses. (a) Features of YAP/TAZ-deficient (YAP off) and YAP/TAZ-positive (YAP on) cancer classes, including the types, genetic and phenotypic characteristics, and key vulnerabilities.(b) Opposite anti- versus pro-oncogenic YAP/TEAD functions in YAP off … prophica ctic antibiotic medicationWebThe demonstration that cancers can be functionally stratified into binary YAP on /YAP off superclasses with distinct therapeutic and genetic vulnerabilities opens a new view on … prophila collection briefmarken zubehörWebBinary pan-cancer classes with distinct vulnerabilities defined by pro- or anti-cancer YAP/TEAD activity Cancer Cell, Volume 39 Supplemental information Binary pan-cancer classes with distinct vulnerabilities defined by pro- or anti-cancer YAP/TEAD activity prophilm tourcoingWebJul 13, 2024 · Cancer heterogeneity impacts therapeutic response, driving efforts to discover over-arching rules that supersede variability. Here, we define pan-cancer … pro-phile photography llc